nder alkaline conditions, mesoporous molecular sieve Ce-MCM-41 was successfully synthesized by using sodium metasilicate as aluminum source, cerium nitrate as cerium source, and cetyltrimethylammonium bromide (CTAB) as structural template. The synthesized Ce-MCM-41 molecular sieve was characterized by XRD and FT-IR. XRD and FT-IR characterization results indicated that Ce atom had entered the framework of MCM-41. The Ce-MCM-41 molecular sieve was used to adsorb and separate nitrides in the oil products. The factors which had a significant effect on the denitrification rate and the optimum technological conditions in certain parameters range were studied. The results show that the optimum conditions for the denitrogenation of simulated oil by Ce-MCM-41 molecular sieve are: 3.0 hours of adsorption time, 80 ℃ of adsorption temperature, 20 mass ratio of oil, the denitrification rate is 85.67%.